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Damage to liver function is still a major problem in many countries in the world, including in Indonesia. Various factors may play a role as a cause, such as hepatitis, consumption of alcohol, drugs, diet and lifestyle. The aim of this study is to determine the potential hepatoprotective activities from the ethanolic leaf extract of Aquilaria malaccensis Lamk. This study conducted a series of tests which include acute toxicity test to determine safe dose range of ethanolic leaf extract, followed by the main test, the hepatoprotective activity test with animal models induced by carbon tetrachloride (CCl4). Animals used in the form of female Wister rats aged 2-3 weeks with the body weight of 100-150 grams. The study began with a single dose acute toxicity test for 14 days followed by a repeated dose toxicity test for 28 days where there are two groups (control and treatment) with each group consisting of three rats. Then, the study continued with the main test using animal models that received treatments for 14 days and then will be induced with CCl4 orally on 15th days where there are 4 groups (Group I, II, III, IV) : Group I will be given 2 ml of 2% tween orally per day; Group II that is the control Silymarin, will be given 140 mg/kg of Legalon® orally per day; Group III will be given 140 mg/kg of ethanolic leaf extract orally per day; Group IV will be given 400 mg/kg of ethanolic leaf extract orally per day. The blood sample will be measured by ALT, bilirubin, ureum and creatinin and histopathology was observed in liver organ. The result was showed that 140 mg/kg ethanolic leaf extract of Aquilaria malaccensis Lamk. has a potential to be the hepatoprotective agent by defending the ALT and bilirubin after CCl4 induced.

hepatoprotective; Aquilaria malaccensis Lamk.; agarwood leaves; acute toxicity